PLN and Myocardial fibrosis: Early PLN-ASO administration strongly reduced formation of myocardial fibrosis in PLN-R14 Δ/Δ mice (~4-fold at 22 weeks), whereas late PLN-ASO administration resulted in collagen deposition at 22 weeks comparable to 8-week-old vehicle-treated PLN-R14 Δ/Δ mice.