POLE and neoplasm: Recently, the results from The Cancer Genome Atlas (TCGA) project revealed four distinct molecular prognostic subgroups based on somatic copy number alterations (SCNAs) and tumor mutational burden that are now included in the molecular WHO Classification of Female Genital Tumors 2020: DNA polymerase-epsilon (POLE) ultramutated ECs, hypermutated ECs with microsatellite instability (MSI), ECs characterized by low copy numbers and mutational burden and ECs characterized by high copy numbers with frequent TP53 mutations [6,7].