Colitis rats induced by 5% DSS and supplemented with 100 mg LBP/kg bw for 4 weeks reduces serum lipid peroxidation substance MDA levels, colonic TNF-α, serum IL-6 levels, and the expression of pain signaling proteins TRPV1 and TRPA1 in the colon, and enhance serum antioxidative CAT activity. The gene discussed is TNF; the disease is colitis.