Mostly, markers of inflammation such as IL-6, IL-10, CXCL10 (also known as IP10), CXCL11, CCL2, CCL7, CCL8, PD-L1, and IL-18R1 were increased at the early stage of COVID-19 in ICU patients compared to non-ICU ones. This evidence concerns the gene IL18R1 and COVID-19.