Recent studies suggest that the intratubular RAS, especially Ang II via activation of AT1 (AT1a) receptors in the proximal tubules of the kidney, plays a key role in basal blood pressure control and the development of Ang II-induced hypertension by regulating proximal tubule Na+ reabsorption and the pressure-natriuresis response [9,10,11]. This evidence concerns the gene AGT and Hypertension.