Specifically, some sex differences have been found in the blood pressure or tubuloglomerular feedback (TGF) responses to Ang II [108,109,110,111], increases in NaCl cotransporter or ENaC expression in response to Ang II [118,119], the development of Ang II-induced hypertension [113], diabetic nephropathy [120], or abdominal aortic aneurysms [121]. Here, AGT is linked to hypertensive disorder.