We and others have recently determined the direct contributions of intratubular Ang II via AT1 (AT1a) receptors in the proximal tubules in the development of Ang II-induced hypertension by comparing global, kidney-, and proximal tubule-specific Agtr1a-/- mice [10,11,12,16,27,28,97,104]. The gene discussed is AGT; the disease is hypertensive disorder.