The TCGA-HSNCC data, accessible at the Genomic Data Commons Data Portal [55], illustrates the top 20 mutated genes (TP53, FAT1, CDKN2A, PIK3CA, NOTHC1, KMT2D, NSD1, CASP8, FAT4, KMT2C, HRAS, CREBBP, FBXW7, AKAP9, NFE2L2, RNF213, SPN, SOS1, and RUNX1T1) in 528 HNSCC cases, which might serve as a highly relevant panel for targeted screening. Here, PIK3CA is linked to head and neck squamous cell carcinoma.