The TCGA-HSNCC data, accessible at the Genomic Data Commons Data Portal [55], illustrates the top 20 mutated genes (TP53, FAT1, CDKN2A, PIK3CA, NOTHC1, KMT2D, NSD1, CASP8, FAT4, KMT2C, HRAS, CREBBP, FBXW7, AKAP9, NFE2L2, RNF213, SPN, SOS1, and RUNX1T1) in 528 HNSCC cases, which might serve as a highly relevant panel for targeted screening. This evidence concerns the gene TP53 and head and neck squamous cell carcinoma.