Dysregulation of the phosphatidylinositol 3-kinase (PI3K) pathway, mitogen-activated protein kinase (MAPK) pathway, catenin beta 1 (CTNNB1), or AT-rich interaction domain 1A (ARID1A or BAF250) appears common in endometrial cancer patients [21]. The gene discussed is CTNNB1; the disease is endometrial cancer.