Meanwhile, mutations in phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), KRAS proto-oncogene, GTPase (KRAS), fibroblast growth factor receptor 2 (FGFR2), protein phosphatase 2 scaffold subunit Aalpha (PPP2R1A), and tumor protein p53 (TP53) have also been identified in endometrioid carcinoma and serous endometrial cancer [21]. This evidence concerns the gene PIK3CA and endometrioid adenocarcinoma.