SNCA and Lewy body dementia: Furthermore, biochemical fractionation from postmortem brains also reported that over 90% of the insoluble α-synuclein proteins found in dementia with Lewy body (DLB) cases are phosphorylated at S129 compared to the 4% seen in healthy brains [17], thereby implicating phosphorylation at this residue as a potential key event in α-synuclein pathology formation, spreading, or clearance.