Comparison analysis of NASH-triggered PHH, HepaRG, and hSKP-HPC cultures exposed to elafibranor unveils that Peroxisome Proliferator Activated Receptor Alpha (PPARA), PPARG Coactivator 1 Alpha (PPARGC1A), and Sirtuin 1 (SIRT1) are the highest expressed common upstream regulators, suggesting that this triad of regulators control the expression of an important subset of genes involved in PPAR-α/δ signaling (Figure 4A). This evidence concerns the gene SIRT1 and metabolic dysfunction-associated steatohepatitis.