We recently showed that human hepatic in vitro models, including primary human hepatocytes (PHH), human skin precursor-derived hepatic progenitor cells (hSKP-HPC), and HepaRG and HepG2 cell lines, can model key NASH-specific cellular mechanisms and capture potential anti-NASH properties of novel compounds such as peroxisome proliferator-activated receptor (PPAR) agonists, a drug class that is under clinical evaluation for anti-NASH treatment [6,7]. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.