PDK4 and metabolic dysfunction-associated steatohepatitis: In addition, an unfiltered comparison analysis of the datasets obtained from the three in vitro NASH models exposed to elafibranor shows that elafibranor commonly modulates 6 genes, namely TDO2, ARG2, and also the previously identified CCL5, ANGPTL4, PDK4, and PLIN2 (Figure 4C).