The mechanistic networks of PPARGC1A, PPARA, and SIRT1 and their downstream modulators based on the datasets of PHH-, HepaRG-, and hSKP-HPC- NASH exposed to elafibranor, unveils common regulation of CCL5, ANGPTL4, PDK4, and PLIN2 (Figure 4B). This evidence concerns the gene PDK4 and metabolic dysfunction-associated steatohepatitis.