PPARGC1A and metabolic dysfunction-associated steatohepatitis: These regulators are, however, known for their NASH-resolving properties, since PPARGC1A1 (i.e., PGC-1α) is a master regulator of mitochondrial biogenesis [28], PPARA expression inversely correlates with histological severity of NASH and recovers upon NASH improvement [29] and deletion of SIRT1, a NAD+-dependent protein deacetylase important for energy homeostasis, results in impaired PPAR-α signaling and decreased fatty acid β-oxidation [30].