Pathway analysis shows that TLR-2, -4, and -9 signaling are activated in NASH-triggered PHH, but only TLR-2 and -9 or TLR-4 and -9 contribute to the inflammatory response in HepaRG and hSKP-HPC, respectively (Figure 2). This evidence concerns the gene TLR2 and metabolic dysfunction-associated steatohepatitis.