The features of stress-induced AEC2 stem cell replicative senescence and SADD in mice are consistent with recent clinical findings that AEC2 stem cells express increased senescence markers, including p16INK4A/CDKN2A, p14INK4B/CDKN2B, TP53 and p21CIP1/CDKN1A [3,4,7], and that AEC2 stem cell SADD existed throughout the course studied in the pneumonia-induced acute respiratory distress syndrome and pulmonary fibrogenesis [4,64,65]. The gene discussed is CDKN2A; the disease is acute respiratory distress syndrome.