Moreover, LSECs are subject to distinct transcriptomic changes according to their localization in cirrhotic livers [87], and various macrophage subtypes have been identified in the context of NASH including lipid-associated macrophages (LAMs), c-LAMs, and embryonic or monocyte-derived KCs [4,88,89]. This evidence concerns the gene TBCE and metabolic dysfunction-associated steatohepatitis.