SREBF1 and metabolic dysfunction-associated steatotic liver disease: Confirming its role in NAFLD pathogenesis, hepatocyte-specific SREBP-1c overexpression leads to induced lipogenesis and hepatosteatosis [46], while the knockout (KO) of SCAP, a protein required for SREBP-1c activity [47], inhibits the expression and rhythmicity of lipogenic genes [29].