LEMD2 and progeroid syndrome: Other progeroid syndromes that arise from mutations in NE-associated proteins include Nestor-Guillermo progeria syndrome (NGPS), caused by a recessive single missense mutation in the small, soluble DNA binding protein barrier-to-autointegration factor (BAF; BANF1) [55,56,57], and LEMD2-associated progeria syndrome (LPS), resulting from an autosomal dominant missense mutation in a TM INM protein called LEM (LAP2, Emerin, MAN1) domain-containing protein 2 (LEMD2; LEMD2) [58].