Thus, dual inhibition of MDM2/4 in primary DNMT3AWT/R882H/NPM1WT/p.W288Xfs*12 AML cells caused cell cycle arrest through upregulation of p53 target genes, in particular p21 and GADD45a, which resulted in growth retardation in vitro. The gene discussed is MDM2; the disease is acute myeloid leukemia.