DEFA4 and COVID-19: For instance, while reducing the correlation between DEGs including IL10, CXCL8, NFKB1, ARG1, and SOD2, new strong associations appeared between ELANE, DEFA4, AZU1, CTSG, and LCN2, with an overall tendency to higher relationships amid neutrophil-mediated immunity genes in COVID-19 patients.