The research performed by Itani et al., Montell et al., and Chavez et al. on human muscle cultures and muscle cell cultures shows that the accumulation of DAG is mostly related to blocking insulin signaling and action, resulting in desensitization to the insulin stimulation of glucose uptake and further resulting in a condition referred to as insulin resistance [43,44,45,46]. The gene discussed is INS; the disease is Insulin resistance.