Given this evidence suggesting an inverse relationship with Alzheimer’s disease and the analogy between W-Tau and 6p/6d containing isoforms, future studies would benefit from exploring the expression of such isoforms in other regions that are less vulnerable to tau pathology, like the cerebellum, where 6p/6d isoforms are found in greater amounts [45]. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.