Among next generation DC maturation cocktails, the work of Kalinski et al. presented one of the most important contributions, demonstrating that combination of toll-like receptor (TLR)-3 stimulation with type I and type II interferons (IFNs) greatly enhances the key anti-tumor DC characteristics, namely antigen presentation, migration in response to chemokine receptor (CCR)-7 ligands, and their capacity to produce IL-12p70 upon CD40-ligand (CD40L) stimulation. Here, CD40LG is linked to neoplasm.