The increased production of IL-12p70 is a hallmark of a quality anti-tumor DC vaccine, since IL-12p70 orchestrates the polarization of CD4+ T cells toward Th1 helper cells during activation, and supports the development and activation of cytotoxic CD8+ T cell (CTL) effectors that kill target tumor cells in an Ag-specific manner [10,11]. This evidence concerns the gene CD4 and neoplasm.