An axon guidance molecule SLIT2 derived from tumour fibroblasts modulates N-cadherin/b-catenin pathway to induce SC proliferation and migration and promote neurite outgrowth [80] Likewise, tumour stroma-derived leukemia inhibitory factor (LIF) activates STAT3 signalling in SCs, leading to SC differentiation and increased neuronal remodelling in PDAC [81]. This evidence concerns the gene CDH2 and neoplasm.