WNK2 and cancer: Based on its strong oxidative power, H2O2 in cancer cells with high proliferative rate could be responsible for the high level of oxidative DNA damage as observed in cancerous thyroid tissue [15] and hyperactivation of some signaling pathways [10] including mitogen-activated protein kinase (MAPK), and PI3K/Akt, involved in ErbB signaling [13,40].