MCUR1 upregulation promotes tumour proliferation and apoptosis avoidance, but also facilitates epithelial–mesenchymal transition (EMT) and metastatic capacity via the ROS/nuclear factor erythroid 2-related factor 2 (Nrf2)/Notch1 pathway in HCC, in both in vitro and in vivo models [147]. Here, NOTCH1 is linked to hepatocellular carcinoma.