These results suggest the contribution of MCUR1-mediated mitochondrial Ca2+ in facilitating HCC EMT by overproducing mtROS, and thus mediates Nrf2 translocation and activates Snail-related EMT via Notch1 and its active form NICD1 [154] (Figure 2). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.