In HCC cell lines (HepG2 and Huh7) and an HCC mouse model, transforming growth factor beta (TGFβ) stimulation (which elevates cytosolic Ca2+ levels via TRPC6 and NCX1 (28)) induces the intrahepatic metastasis of HCC; alternatively, knockdown of TRPC6 or NCX1 inhibits this metastatic development. The gene discussed is TGFB1; the disease is hepatocellular carcinoma.