LHX2 and microphthalmia: While Lhx2 mutants are anophthalmic, display hypoplasia of the neocortex and severe anaemia, neuroretina specific loss of function of Lhx2 causes severe microphthalmia, loss of expression of a subset of retinal progenitor cell-specific genes, and ectopic expression of hypothalamic genes [134,140,142].