Although in this research neither EV nature or composition, nor the presence and contribution of CAR and proapoptotic proteins in the EV to tumor rejection, have been established, this strategy opens new venues based on improved endogenous immunity against tumor cells conferred by EV, since CAR T cells can now co-deploy antigenic peptides with RN7SL1 released by EV to enhance their efficacy against tumor cells, even when tumors lack adequate neoantigens [140]. This evidence concerns the gene RN7SL1 and neoplasm.