Compared with women with normal pregnancies, plasma concentrations of the cerebral biomarkers were higher in plasma from women with preeclampsia; NfL (5.25 ng/L, IQR 3.93–7.63 ng/L vs. 8.85 ng/L, IQR 6.78–12.65 ng/L, p < 0.001); tau (2.40 ng/L, IQR 1.80–2.58 ng/L vs. 2.90 ng/L, IQR 2.40–4.35 ng/L, p < 0.05); NSE (2.37 μg/L, IQR 1.93–2.85 μg/L vs. 3.50 μg/L, IQR 2.84–4.55 μg/L, p < 0.001) and S100B (0.05 μg/L, IQR 0.03–0.08 μg/L vs. 0.08 μg/L, IQR 0.05–0.10 μg/L, p < 0.01) (Figure 1a–d). The gene discussed is S100B; the disease is preeclampsia.