Higher plasma concentrations of NfL were found in the women with preeclampsia that expressed severe headache than in the women with mild or no headache (11.65 ng/L, IQR 9.58–15.63 ng/L vs. 7.40 ng/L, IQR 5.93–9.93 ng/L, p = 0.024). This evidence concerns the gene NEFL and preeclampsia.