For example, both the PTEN signaling and HIPPO signaling pathways increased over time, whereas the canonical pathways of IL-17A signaling in airway cells, signaling by Rho family GTPases, p70S6K signaling, thrombin signaling, role of NFAT in cardiac hypertrophy, ErbB2-ErbB3 signaling, and leukocyte extravasation signaling continued to decrease. This evidence concerns the gene ERBB2 and cardiac hypertrophy.