ACE and heart failure: Many effective cardiovascular drugs, such as angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists, and sodium-glucose co-transporter-2 (SGLT2) inhibition, are available for patients with heart failure with reduced ejection fraction (HFrEF) [7,8,9].