We [38,45] and other investigators [46,47,48,49,50,51] have found that MIR139 is a tumor suppressor gene that is frequently silenced in leukemia, including Fanconi anemia-related leukemia, caused by interstrand crosslink (ICL)-induced DNA damage [45], Breakpoint Cluster Region Protein-Abelson Murine Leukemia Viral Oncogene Homolog 1(BCR-ABL)-mediated leukemogenesis [49], AML [46,47] and T-cell acute lymphoblastic leukemia [51]. The gene discussed is MIR139; the disease is acute myeloid leukemia.