CXCR4 and non-small cell lung carcinoma: We compared serum sEVs from the HDs, E/NSCLCs and A/NSCLCs, and found that the expressions of EGFR and CXCR4 on serum sEVs were significantly higher in A/NSCLCs compared to HDs and E/NSCLCs, suggesting the capability of serum sEV EGFR and CXCR4 for the diagnosis of NSCLC.