EGFR and non-small cell lung carcinoma: To evaluate the discriminative efficacy of EGFR and CXCR4 in serum sEVs to diagnose NSCLC, we performed ROC analysis on serum sEV EGFR and CXCR4 in classifying NSCLC patients (including E/NSCLC, n= 16 and E/NSCLC, n = 17 and HDs, n = 18).