UBE2E3 and cancer: In addition, extensive research suggests that SLs exercise their antitumor effects by reacting on proteins and enzymes or interfering with some key biological processes, including the sarco/endoplasmatic reticulum calcium ATPase pump, proteases, transferrin receptors, nuclear factor-kappa B, and E3 ubiquitin-protein ligase Mdm2, as well as the p53 gene, angiogenesis, and metastasis in cancer cells [8,9].