KRAS and non-small cell lung carcinoma: Sotorasib (21, brand name Lumakras®) is a Rat Sarcoma (RAS) GTPase family inhibitor developed by Amgen for the treatment of solid tumors with Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) mutations, including non-small cell lung cancer (NSCLC) and colorectal cancer.