SARS-CoV-2-and COVID-19-associated dysfunctional endothelium is characterized by dysregulation and disruption of endothelial homeostasis toward a pro-inflammatory phenotype, hyperproduction of inflammatory cytokines including IL-6, IL-8, and TNF-α and dysregulation of coagulation, vascular tone, endothelial permeability, and vascular inflammation. Here, CXCL8 is linked to COVID-19.