Garlic and onions have anti-obesity effects, such as decreasing cholesterol synthesis via hepatocytes by inhibiting HMG-CoA (β-Hydroxy β-methylglutaryl-CoA) reductase, preventing the platelet aggregation, inhibiting inflammatory enzyme activity, decreasing iNOS (Inducible Nitric Oxide Synthase) expression in macrophages, and decreasing the fabrication of inflammatory signaling molecules and fetoprotein [133]. The gene discussed is NOS2; the disease is obesity due to melanocortin 4 receptor deficiency.