In our study, 415 mRNAs were found to be associated with the effect of 20(R)-Rg3 on stroke recovery, while the expression of these genes, such as Tagln, Vim, Ptges, Pax1, Cxcl3 and Ccl20, was also significantly altered in our sequencing results. The gene discussed is CXCL3; the disease is Stroke.