Reportedly, AD is caused by immunological abnormalities and/or epidermal barrier dysfunction, which are associated with the complex interplay between genetic, immunological (increased serum immunoglobulin-E (IgE) levels and imbalance between T helper type 1 (Th1) and Th2 cells) responses, and environmental factors such as environmental pollution [2]. This evidence concerns the gene IGHE and Alzheimer disease.