Whether the neuroprotective effect of MTC on induced cerebral ischemia in the rat middle cerebral artery occlusion (MCAO) model is due to the activation of the TREK-1 channel, and if so, whether there is a possible relationship between the mechanism of action of MTC and the TREK-1 channel, needs to be delineated further. Here, KCNK2 is linked to brain ischemia.