Although approximately two decades of investigations have established that TGF-α performs a critical function in the pathogenesis of PF by activating, proliferating, and differentiating collagen-producing myofibroblasts and epithelial cells, no advancement has been reported in translating TGF-α cascade antagonists from the platform to the bedside [38,39]. Here, TGFA is linked to pemphigus foliaceus.