SOX2 and small cell lung carcinoma: Furthermore, the SCLC-like subset harbored exclusive alterations of SCLC, e.g., v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog gene (MYCL) amplification, sex-determining region Y (SRY)-box 2 (SOX2) amplification, phosphatase and tensin homolog (PTEN) mutation/loss and Fibroblast Growth Factor Receptor 1 (FGFR1) amplification, with complete absence of STK11 and KRAS mutations, whereas the NSCLC-like subset occasionally showed SCLC typical alterations (e.g., MYCN amplification).