Interestingly, STK11 mutations were more frequent in NSCLC-like LCNEC compared to lung LUAD (60% vs. 16%, respectively), suggesting that STK11 mutations, which are associated with rapid tumor growth and metastasis in lung LUAD, can explain the aggressive clinical behavior of LCNEC, as observed in NSCLC [31]. This evidence concerns the gene STK11 and large cell neuroendocrine carcinoma.