VWF and COVID-19: Beyond the hypothesis of direct viral mechanisms, systemic inflammation plays an additional role in the disruption of endothelial barrier integrity in COVID-19, since inflammatory cytokines from activated leukocytes are able to bind to specific receptors on ECs, thus enhancing the expression of a number of mediators and adhesion molecules, including intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and von Willebrand factor (vWF) [2,27].