Given the scarcity of studies about MSR1 expression in PBMCs and its potential association with different pathologies, including respiratory diseases, the present study aimed to corroborate the expression of MSR1 in PBMCs, determine its association with asthma and COPD, and characterize the PBMCs’ cellular subpopulations that express this receptor. Here, MSR1 is linked to chronic obstructive pulmonary disease.