Mutations that affect TP53, RB1, PIK3CA, as well as acquired EGFR mutations, such as C797S, have also been reported to be associated with SCLC transformation, but, similar to our cohort, the results are not yet conclusive to arrive at a definitive resistance profile suggesting a possible non-genetic mechanism such as EMT may be at play [6,7,11]. This evidence concerns the gene RB1 and small cell lung carcinoma.