After adjusting for age, sex, and the presence of obesity, the increased AHI in participants with prediabetes was mainly associated with increments in the hypopnea events, supporting the hypothesis that glucose abnormalities exert a lineal negative impact on SBD, from insulin resistance with normal fasting glucose to confirmed diagnosis of type 2 diabetes. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.