Most patients in both groups took drugs for the treatment of cardiovascular diseases, including agents acting on the renin-angiotensin system (52.4 [53.3]% (n = 55 [n = 49]) in the Subetta group and 53.6 [52.4]% (n = 52 [n = 43]) in the Placebo group; p = 0.89 [p] = 1.00]), beta blocking agents (30.5 [29.3]% (n = 32 [n = 27]) and 26.8 [29.3]% (n = 26 [n = 24]); p = 0.64 [p = 1.00]), calcium channel blockers (13.3 [15.2]% (n = 14 [n = 14]) and 10.3 [9.8]% (n = 10 [n = 8]), respectively; p = 0.52 [p = 0.36]). This evidence concerns the gene REN and cardiovascular disorder.