The following keywords were used: T2DM, insulin resistance, NAFLD, fatty liver, nonalcoholic fatty liver, nonalcoholic steatohepatitis, diagnosis, ultrasonography, transient elastography, complications, treatment, metformin, thiazolidinediones, GLP-1 agonists and DPP-4 inhibitors. The gene discussed is GCG; the disease is metabolic dysfunction-associated steatotic liver disease.