As far as lung fibrosis is concerned, serum SIRT3 levels were found to be decreased in SSc patients diagnosed with ILD on HRCT scans of the chest (median 0.27 ng/mL, IQR 0.20–0.57 ng/mL) compared to those without ILD (median 0.47 ng/mL, IQR 0.32–0.86 ng/mL; p = 0.005; Figure 5A). Here, SIRT3 is linked to pulmonary fibrosis.