As far as peripheral microvascular involvement is concerned, circulating SIRT3 levels were found to be different between SSc patients with ischemic DUs (median 0.33 ng/mL, IQR 0.15–0.62 ng/mL) and those without DUs (median 0.45 ng/mL, IQR 0.28–0.80 ng/mL; p = 0.031; Figure 6A), as well as between SSc patients with “early” NVC (median 0.62 ng/mL, IQR 0.32–1.00 ng/mL) and those with “active/late” NVC (median 0.32 ng/mL, IQR 0.20–0.61 ng/mL; p = 0.003; Figure 6B). Here, SIRT3 is linked to systemic sclerosis.