SIRT3 and systemic sclerosis: When stratifying patients according to the SSc cutaneous subsets, we found that SIRT3 levels were significantly lower in dcSSc (median 0.28 ng/mL, IQR 0.17–0.47 ng/mL), but not in lcSSc patients (median 0.56 ng/mL, IQR 0.30–0.86 ng/mL) compared with controls (p < 0.001; Figure 4A).