SIRT3 levels were found to be significantly lower in patients with SSc (median 0.37 ng/mL, IQR 0.20–0.66 ng/mL) compared to controls (median 0.49 ng/mL, IQR 0.35–0.88 ng/mL; p = 0.004; Figure 4A). This evidence concerns the gene SIRT3 and systemic sclerosis.