Despite the fact that low levels of plasma apoA-I were shown to independently predict the poor clinical outcome of patients with invasive ductal breast cancer [7], a large study conducted on 1411 women from the AMORIS cohort with breast cancer severity known only found a modest positive association between the apoB100-to-apoA-I ratio and breast cancer severity [14]. The gene discussed is APOA1; the disease is breast carcinoma.