A 35-year-old normotensive man with c.658C > T mutation of GLA and 0% alpha-galactosidase A activity in leukocytes, denoting a classic form of Fabry disease, was admitted because of chest discomfort and palpitations, hypertrophic cardiomyopathy of mild severity (left ventricular maximal wall thickness 14 mm), short PR interval at ECG and concomitant abdominal pain with diarrhea. The gene discussed is GLA; the disease is Fabry disease.