Because of their effects on the antioxidant enzyme system, including lipoxygenases (LOXs), myeloperoxidase (MPO), nicotinamide adenine dinucleotide phosphate (NAD[P]H) oxidase, catalase, GPX, and superoxide dismutase (SOD) [18,19,20], statins can reduce atherosclerosis by their antioxidant effects. The gene discussed is MPO; the disease is atherosclerosis.