IL1B and type 1 diabetes mellitus: In this systematic review, significantly higher IL-1β peripheral levels in T1DM patients compared to healthy subjects were shown, according to the meta-analysis on the determination of IL-1β by immunoassays from serum or plasma (SMD = 2.45, 95% CI = 1.73 to 3.17; p < 0.001; n = 20 primary-level studies/3490 patients).