Regarding the participation of other pro-inflammatory cytokines, such as TNF-α and IL6, in patients with T1DM, these were found to be linked to elevated level of serum IL-6 and TNF-α, on which the age, ethnicity, and disease duration [12,13] in T1DM patients had no effect on the serum IL-6 levels for promoting diabetes mellitus. This evidence concerns the gene TNF and diabetes mellitus.