Compared with the current clinical classification systems, including the Barcelona clinic liver cancer (BCLC) stage, the tumor node metastasis (TNM) stage, and the albumin-bilirubin (ALBI) grade, the GPI score presented a notable performance according to the time-dependent receiver operating, and might stand as a helpful tool to stratify the HCC prognostic risk after surgery [34]. This evidence concerns the gene ALB and neoplasm.