IL1B and Behcet disease: Nevertheless, several important factors need to be taken into consideration before drawing precise conclusions: (a) most AIDs present early in life and are associated with a monogenic mutation, which is not the case in BD [30]; (b) vasculitis is not a prominent feature of monogenic AIDs (with some notable exceptions), whereas a substantial number of BD patients display vascular involvement at presentation or over the disease course [30]; (c) anti-IL1ß therapies that have been successfully used in AIDs caused by defects in the inflammasome have not been convincingly effective for BD [14].