With regard to the last of the therapies mentioned in the previous sentence, it should be noted that the studies, which concerned the influence of ECM protein overexpression on tamoxifen therapy, provided the conclusions that increased levels of tenascin C, ON and fibronectin in TME predispose cancer cells to exhibit resistance to therapy with selective estrogen receptor modulators and, moreover, indicate poor prognosis [290]. This evidence concerns the gene TNC and cancer.