TNC has the ability to modulate cancer stem cell signaling by enhancing expression of key regulators of the Wnt and Notch pathways, namely leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) and musashi homolog 1 (MSI1), respectively, which has been associated with an increased risk of recurrence (local and distant) [135,215,233]. Here, LGR5 is linked to cancer.